Rate of treatment-emergent mania with OFC Author: Keck, et al. Title: Analysis of treatment-emergent mania with olanzapine/fluoxetine combination Reference: World J Psychiatry 2004;5(Suppl 1):50. [Congress abstract] Also: European Neuropsychopharmacology. The Journal of the European College of Neuropsychopharmacology 2003;13(Suppl 4):S212. Purpose: Efficacy trial of OFC in rapid-cycling bipolar depression. Study design: Randomized, double-blinded trial (secondary analysis addressing treatment-emergent mania). Follow up: 8 weeks. Patients: 833 (86 OFC, 370 olanzapine, and 377 placebo). Treatment:OFC (6 and 25, mg/day, 6 and 50 mg/day, or 12 and 50 mg/day), olanzapine (5–20 mg/day), or placebo. Results: Risk of treatment-emergent mania with olanzapine or OFC treatment was not greater than placebo.
