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 | | | | | | | Efficacy of olanzapine as maintenance therapy
Author: Sanger, et al.
Title: Long-term olanzapine therapy in the treatment of bipolar I disorder: an open label continuation phase study.
Reference: J Clin Psychiatry 2001;62:273–81.
Purpose: Open-label, extension trial of olanzapine maintenance treatment in patients with bipolar disorder.
Study design: Noncomparative.
Follow up: 49 Weeks.
Patients: 113 patients.
Treatment: Olanzapine (mean modal dose 13.9 mg/day).
Results: Significant improvements in the manic and depressive symptoms of patients were observed with olanzapine. Depression was reported as an adverse event in 39% of patients. Mean weight gain was 6.6 kg.
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