| | Switch rates with 2nd-generation antidepressants
Authors: Post RM, et al.
Title: Rate of switch in bipolar patients prospectively treated with second-generation antidepressants as augmentation to mood stabilizers.
Reference: Bipolar Disorders 2001;3:259-65.
Purpose: To assess switch rates in patients receiving SSRI, bupropion, or venlafaxine add-on therapy to a mood stabilizer.
Study design: Double-blinded trial with a 1-year, blinded, continuation phase.
Follow up: 10-week acute phase with a 1-year follow-up.
Patients: 64 outpatients with bipolar depression.
Treatment: SSRI, bupropion, or venlafaxine add-on therapy to lithium, carbamazepine, or valproate treatment.
Results: 14% of patients switched to mania or hypomania during the 10-week acute phase and 33% switched to mania or hypomania during the one-year follow-up. As the study is still ongoing, the blinding of treatment had not been broken at the time of writing, so the individual data on each antidepressant were not yet available.selective serotonin reuptake inhibitor selective serotonin reuptake inhibitor
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