| | OFC: quality of life in bipolar depression
Author: Shi, et al.
Title: Effects of olanzapine alone and olanzapine/fluoxetine combination on health related quality of life in patients with bipolar depression: secondary analysis of a double blind, placebo-controlled randomized trial.
Reference: Clin Ther 2004;26:125-34.
Purpose: Secondary analysis to investigate the effect of OFC on HR-QoL.
Study design: Randomized, double-blinded trial (secondary analysis).
Follow up: 8 weeks.
Patients: 833 (86 OFC, 370 olanzapine, and 377 placebo).
Treatment: OFC (6 and 25 mg/day, 12 and 25 mg/day, or 12 and 50 mg/day), olanzapine (5–20 mg/day), or placebo.
Results: Long-term treatment with olanzapine or OFC improved HR-QoL in bipolar depressed patients compared with placebo. OFC improved HR-QoL to a greater extent than olanzapine alone.health-related quality of life health-related quality of life health-related quality of life olanzapine fluoxetine combination olanzapine fluoxetine combination olanzapine fluoxetine combination olanzapine fluoxetine combination olanzapine fluoxetine combination quality of life quality of life quality of life
| | | |
