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 | | | | | | | Antidepressant-induced switch rates
Authors: Serretti A et al.
Title: Clinical features of antidepressant associated manic and hypomanic switches in bipolar disorder.
Reference: Prog Neuropsychopharmacol Biol Psychiatry 2003;27:751-7.
Purpose: To identify clinical features associated with antidepressant-induced affective switch in patients with bipolar disorder.
Study design: Retrospective chart review.
Follow up: Variable.
Patients: 169 patients with bipolar I and II disorder.
Treatment: Various, including a variety of antidepressants and mood stabilizers.
Results: Switching to mania or hypomania occurred in 51% of patients receiving an antidepressant alone and in 17% of patients receiving concomitant therapy with a mood-stabilizer.
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