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 | | | | | | | Paroxetine versus second mood stabilizer
Authors: Young et al.
Title: Double-blind comparison of addition of a second mood stabilizer versus an antidepressant to an initial mood stabilizer for treatment of patients with bipolar depression.
Reference: Am J Psychiatry 2000;157:124-6.
Purpose: Comparing the addition of an antidepressant versus a second mood stabilizer for the treatment of bipolar depression in patients treated with lithium carbonate or divalproex sodium.
Study design: Randomized, double-blinded trial.
Follow up: 6 weeks.
Patients: 27 patients.
Treatment: Paroxetine or second mood stabiliser.
Results: Both treatment groups showed significant improvement in depressive symptoms during the 6-week trial. There were significantly more noncompleters in the group treated with two mood stabilizers compared with the number of noncompleters in the group treated with a mood stabilizer and paroxetine.
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