Ziprasidone in acute bipolar mania (1) Authors: Keck PE, et al. Title: Ziprasidone in the treatment of acute bipolar mania: a three-week, placebo-controlled, double blind, randomized trial. Reference:Am J Psychiatry 2003;160:741-8. Purpose: To evaluate the efficacy and tolerability of ziprasidone in the treatment of acute bipolar mania. Study design: Randomized, double-blinded, placebo-controlled trial. Follow up: 3 weeks. Patients: 210 patients (140 ziprasidone, 70 placebo). Treatment: ziprasidone 40–80 mg twice daily. Results: Significant improvements were observed within 2 days in all primary efficacy measures in ziprasidone-treated patients compared with placebo-treated patients. Ziprasidone, was well tolerated with a low rate of EPS.
