More patients remain on olanzapine therapy compared with lithium in the maintenance of bipolar disorder

During a head-to-head maintenance trial of olanzapine versus lithium, significant differences were observed favoring olanzapine over lithium when assesing time to discontinuation for any reason and overall completion rate (presented as a poster at scientific meetings including the International Congress of Biological Psychiatry, Sydney, Australia, 2004).

GSK counterclaim:

Weight gain has been observed with olanzapine treatment in every clinical trial presented to date. Depression and somnolence are consistently among the most frequently observed side effects with olanzapine maintenance treatment (Support data 1 and 2).