Authors: Biederman, et al.
Title: Therapeutic dilemmas in the pharmacotherapy of bipolar depression in the young.
Reference: J Child and Adolescent Psychopharmacol 2000;10:185-92.
Purpose: To assess the risk and benefits of SSRI treatment in young patients with bipolar depression.
Study design: Retrospective chart review.
Follow up: Not applicable.
Patients: 59 children with bipolar I depression (mean age 11 years).
Treatment: SSRI treatment in a naturalistic setting.
Results: SSRI therapy increased the rate of improvement of bipolar depression in young patients, but was associated with a 3-fold increase in the relative risk of manic symptomatology.